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Color-coded biosensor illuminates in real time how viruses attack hosts

All viruses can only do damage by replicating inside the cells of another organism, their host. Researchers have now shown an important mechanism in this host-attacking process, at the single-molecule level in living cells.

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Color-coded biosensor illuminates in real time how viruses attack hosts

All viruses can only do damage by replicating inside the cells of another organism, their host. Researchers have now shown an important mechanism in this host-attacking process, at the single-molecule level in living cells.

Color-coded biosensor illuminates in real time how viruses attack hosts

All viruses can only do damage by replicating inside the cells of another organism, their host. Researchers have now shown an important mechanism in this host-attacking process, at the single-molecule level in living cells.

New brain cell-like nanodevices work together to identify mutations in viruses

Scientists have described a new nanodevice that acts almost identically to a brain cell. Furthermore, they have shown that these synthetic brain cells can be joined together to form intricate networks that can then solve problems in a brain-like manner.

A new strategy of cell entry for some types of parvoviruses

(Institut national de la recherche scientifique – INRS) Researchers at the Institut national de la recherche scientifique (INRS), in collaboration with American scientists, have uncovered a new parvovirus strategy for reaching the cell nucleus which is their site of replication. This new method of entry is a good example of host-driven evolution. Their results were published in the journal Proceedings of the National Academy of Sciences of the United States of America.

Likely molecular mechanisms of SARS-CoV-2 pathogenesis are revealed by network biology

Researchers have built an interactome that includes the lung-epithelial cell host interactome integrated with a SARS-CoV-2 interactome. Applying network biology analysis tools to this human/SARS-CoV-2 interactome has revealed potential molecular mechanisms of pathogenesis for SARS-CoV-2, the virus responsible for the COVID-19 pandemic. The research identified 33 high-value SARS-CoV-2 therapeutic targets, which are possibly involved in viral entry, proliferation and survival to establish infection and facilitate disease progression.

A cheaper, faster COVID-19 test

Researchers have developed a method for fast, cheap, yet accurate testing for COVID-19 infection. The method simplifies and frees the testing from expensive reaction steps, enabling upscaling of the diagnostics.

New drug candidate found for hand, foot and mouth disease

Researchers have identified a potential drug candidate against enterovirus 71, a common cause of hand, foot and mouth disease in infants and young children. The compound of interest is a small molecule that binds to RNA, the virus’s genetic material, and changes its 3-D shape in a way that stops the virus from multiplying without harming its human host. It’s an antiviral strategy that could be used on other hard-to-treat diseases.

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Key role of immune cells in brain infection

Researchers have identified the specific type of immune cell that induces brain inflammation in herpes simplex virus (HSV) encephalitis. Crucially, they have also determined the signalling protein that calls this immune cell into the brain from the bloodstream. The findings could aid the development of targeted treatments for the brain infection, which is the most common cause of viral encephalitis worldwide.